Analytical, Synthetic, and Computational Natural Products Chemistry
A brief overview
Mono- and dimeric naphthylisoquinoline alkaloids (e.g., dioncophylline C): isolation from Ancistrocladaceae and Dioncophyllaceae plants, structural elucidation, biosynthesis studies, partial and total synthesis; cultivation of plants and plant tissue cultures; in vivo NMR imaging and NMR microscopy. - Bioassay-guided search for new bioactive (e.g., antimalarial, antiviral, antifungal, antileishmanial, antitrypanosomal, and antifeedant) compounds from tropical medicinal plants and marine organisms using our novel 'triade': LC coupled to NMR, MS/MS and CD. - Novel concepts in regio- and stereoselective biaryl synthesis, e.g., the atroposelective cleavage of biaryl lactones: mechanistic investigation and preparative exploration within the total syntheses of chiral biaryls as bioactive drugs or as tools in asymmetric synthesis. - Computational Chemistry: calculation of structures, dynamics, and chemical reactivities of molecules, prediction of CD spectra, QSAR investigations using the CoMFA (Comparative Molecular Field Analysis) technique, novel algorithms for the scanning of energy hypersurfaces (e.g., 'AdaptivSearch'). - Endogenous Alkaloids in Man: In vivo formation, metabolism, and medicinal relevance of chloral-derived tetrahydro-b-carbolines (e.g., 'TaClo') for neurodegeneration.