Intern
    THE HÖBARTNER GROUP: ORGANIC AND BIOMOLECULAR CHEMISTRY

    2017

     

    57

    T. J. Carrocci, L. Lohe, M. J. Ashton, C. Höbartner and A. Hoskins,
    Debranchase-resistant labeling of RNA using the 10DM24 deoxyribozyme and fluorescent modified nucleotides.
    Chem. Commun. 2017, 53, 11992-11995. 

    56

    M.A. Gomes de Castro, C. Höbartner, F. Opazo,
    Staining of Membrane Receptors with Fluorescently-labeled DNA Aptamers for Super-resolution Imaging.
    Bio-protocol 7(17): e2541.

    55

    P. Bao, C. Höbartner, K. Hartmuth, R. Lührmann,
    Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing.
    RNA 2017

    54

    S. Haag, K.E. Sloan, C. Höbartner, M.T. Bohnsack, In Vitro Assays for RNA Methyltransferase Activity.
    Methods Mol Biol.
    2017, 1562:259-268.

    53

    M.A. Gomes de Castro, C. Höbartner, F. Opazo, Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy.PLoS One 2017, 12, e0173050.  

    52

    K.E. Sloan, C. Höbartner, M.T. Bohnsack, How RNA modification allows nonconventional decoding in mitochondria.
    Cell Cycle
    2017, 16, 145-146. (invited Feature) 

    2016

     

    51

    S. Haag, K.E. Sloan, N. Ranjan, A.S. Warda, J. Kretschmer, C. Blessing, B. Hübner, J. Seikowski, S. Dennerlein, P. Rehling, M.V. Rodnina, C. Höbartner, M.T. Bohnsack,
    NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation.EMBO Journal 2016, 35, 2104-2119. SI

     

    comments by others:
    F. Boos, M. Wollin, J.M. Herrmann, Methionine on the rise: how mitochondria changed their codon usage.
    News & Views EMBO J. 2016 Aug 30. 

    50

    A. Ponce-Salvatierra, K. Wawrzyniak-Turek, U. Steuerwald, C. Höbartner, V. Pena, Crystal structure of a DNA catalyst.
    Nature 2016, 529, 231-234. 

     

    comments by others:
    K. Woolcock, Structure of a DNA enzyme.
    Nat. Struct. Mol. Biol. 2016, 23, 97.
    T.L. Sheppard, Catalytic DNA: Ligating with lambda.
    Nat. Chem. Biol. 2016, 12, 125.
    M. Kostic, Select: Structure of a DNAzyme.
    Cell Chem Biol. 2016 Feb 18;23(2):200.
    J. Wirmer-Bartoschek, H. Schwalbe, Understanding How DNA Enzymes Work.
    Angew. Chem. Int. Ed.
    2016, 55, 5376.
    Press release: MPIbpc, Univ. Göttingen
    F1000Prime Recommendationsby S.K. Silverman; D. Wetmore; B. Seelig; I. Hirao; total score: 11. 
    Scientists Report First Crystal Structure Of A DNAzyme C&E News

    49

    M. Theuser, C. Höbartner, M.C. Wahl, K.F. Santos, Substrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase. Proc. Natl. Acad. Sci. USA. 2016, 113, 7798-7803. SI

    48

    B. Samanta, J. Seikowski, C. Höbartner, Fluorogenic labeling of 5-formylpyrimidines in DNA and RNA.
    Angew. Chem. Int. Ed. 2016, 55, 1912-1916. SI

    47

    F. Javadi-Zarnaghi, C. Höbartner, Functional hallmarks of a catalytic DNA that makes lariat RNA.
    Chem. Eur. J. 2016, 22, 3720-3726. SI

    46

    K. Halbmair, J. Seikowski, I. Tkach, C. Höbartner, D. Sezer, M. Bennati, High-resolution measurement of long-range distances in RNA: pulse EPR spectroscopy with TEMPO-labeled nucleotides. Chem. Sci. 2016, 7, 3172-3180. SI

    45

    S. Kwiatkowski, V.M. Sviripa, Z. Zhang, A.E. Wendlandt, C. Höbartner, D.S. Watt*, S. Stamm*, Synthesis of a norcantharidin-tethered guanosine: Protein phosphatase-1 inhibitors that change alternative splicing. Bioorg Med Chem Lett. 2016, 26, 965-968. SI (* co-corresponding author)

    2015

     

    44

    M. Kosutic, S. Neuner, A. Ren, S. Flür, C. Wunderlich, E. Mairhofer, N. Vusurovic, J. Seikowski, K. Breuker, C. Höbartner, D.J. Patel, C. Kreutz, R. Micura, A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class. Angew. Chem. Int. Ed. 2015, 54, 15128-15133. SI

    43

    S. Haag, A.S. Warda, J. Kretschmer, M.A. Günnigmann, C. Höbartner, M.T. Bohnsack, NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs. RNA 2015, 21, 1532-1543. SI

    42

    B. Schmidtgall, C. Höbartner, C. Ducho, NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A-T phosphoramidite building blocks. Beilstein J. Org. Chem. 2015, 11, 50-60. SI

    41

    E. Turriani, C. Höbartner, T.M. Jovin, Mg2+-dependent conformational changes and product release during DNA-catalyzed RNA ligation monitored by Bimane fluorescence. Nucleic Acids Res. 2015, 43, 40-50. SI

    40

    Z. Warkocki, C. Schneider, S. Mozaffari-Jovin, J. Schmitzová, C. Höbartner, P. Fabrizio, R. Lührmann, The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome. Genes Dev. 2015, 29, 94-107. SI

    2014

     

    39

    C.C. Lin, J. Seikowski, A. Pérez-Lara, R. Jahn, C. Höbartner, P.J. Walla, Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler. Nat. Commun. 2014 Dec 15; 5, 5859. SI

    38

    L. Büttner, F. Javadi-Zarnaghi, C. Höbartner, Site-specific labeling of RNA at internal ribose hydroxyl groups: terbium-assisted deoxyribozymes at work. J. Am. Chem. Soc. 2014, 136, 8131-8137. SI

    37

    K. Wawrzyniak-Turek, C. Höbartner, Enzymatic combinatorial nucleoside deletion scanning mutagenesis of functional RNA. Chem. Commun. 2014, 50, 10937-10940. SI

    36

    K. Wawrzyniak-Turek, C. Höbartner, Deoxyribozyme-mediated ligation for incorporating EPR spin labels and reporter groups into RNA. Methods Enzymol. 2014, 549, 85-104.

    35

    B. Schmidtgall, F. Wachowius, C. Höbartner, C. Ducho, Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure. Chem. Commun. 2014, 50, 13742-13745. SI

    34

    I. Tkach, K. Halbmair, C. Höbartner, M. Bennati, High-frequency 263 GHz PELDOR.
    Appl. Magn. Res. 2014, 45, 969-979.

    2013

     

    33

    F. Javadi-Zarnaghi, C. Höbartner, Lanthanide cofactors accelerate DNA-catalyzed synthesis of branched RNA.
    J. Am. Chem. Soc. 2013, 135, 12839-12848. SI

    32

    L. Büttner, J. Seikowski, K. Wawrzyniak, A. Ochmann, C. Höbartner, Synthesis of spin-labeled riboswitch RNAs using convertible nucleosides and DNA-catalyzed RNA ligation. Bioorg. Med. Chem. 2013, 21, 6171-6180. SI

    31

    B. Samanta, C. Höbartner, Combinatorial Nucleoside-Deletion-Scanning Mutagenesis of Functional DNA. Angew. Chem. Int. Ed. 2013, 52, 2995-2999. Angew. Chem. 2013, 125, 3069-3073. SI

    30

    I. Tkach, S. Pornsuwan, C. Höbartner, F. Wachowius, S.T. Sigurdsson, T. Baranova, U. Diederichsen, G. Sicoli, M. Bennati, Orientation selection in distance measurements between nitroxide spin labels at 94 GHz EPR with variable dual frequency irradiation. Phys. Chem. Chem. Phys. 2013, 15, 3433-3437. SI

    2012

     

    29

    C. Höbartner*, G. Sicoli, F. Wachowius, D.B. Gophane, S.T. Sigurdsson*, Synthesis and Characterization of RNA Containing a Rigid and Nonperturbing Cytidine-Derived Spin Label. J. Org. Chem. 2012, 77, 7749-7754. SI (* co-corresponding authors)

    28

    G.N. Nawale, K.R. Gore, C. Höbartner*, P.I. Pradeepkumar*, Incorporation of 4'-C-aminomethyl-2'-O-methylthymidine into DNA by thermophilic DNA polymerases. Chem. Commun. 2012, 48, 9619-9621. (* co-corresponding authors)

    27

    K.R. Gore, G.N. Nawale, S. Harikrishna, V. G. Chittoor, S.K. Pandey, C. Höbartner, S. Patankar, P.I. Pradeepkumar, Synthesis, Gene Silencing, and Molecular Modeling Studies of 4'-C-Amino-methyl-2'-O-methyl Modified Small Interfering RNAs. J. Org. Chem. 2012, 77, 3233-3245. SI

    2011

     

    26

    F. Wachowius, C. Höbartner, Probing essential nucleobase functional groups in aptamers and deoxyribozymes by nucleotide analog interference mapping of DNA. J. Am. Chem. Soc. 2011, 133, 14888-14891. SI

    25

    C. Höbartner, Enzymatic labeling of 5-hydroxymethylcytosine in DNA.
    Angew. Chem. Int. Ed. 2011, 50, 4268-4270. Angew. Chem. 2011, 123, 4357-4359. (Highlight)

    24

    I. Tkach, G. Sicoli, C. Höbartner and M. Bennati, A dual-mode microwave resonator for double electron-electron spin resonance spectroscopy at W-band microwave frequencies. J. Mag. Res. 2011, 209, 341-346.

    23

    N. Dixit, R.K. Koiri, B.K. Maurya, S.K. Trigun, C. Höbartner, L. Mishra, One pot synthesis of Cu(II) 2,2'-bipyridyl complexes of 5-hydroxy-hydurilic acid and alloxanic acid: Synthesis, crystal structure, chemical nuclease activity and cytotoxicity. J. Inorg. Biochem. 2011, 105, 256-267.

    2010

     

    22

    F. Wachowius, F. Javadi-Zarnaghi, C. Höbartner, Combinatorial Mutation Interference Analysis reveals functional nucleotides required for DNA catalysis. Angew. Chem. Int. Ed. 2010, 49, 8504-8508. Angew. Chem. 2010, 122, 8682-8687. SI

     

    comments by others
    comment in Faculty of 1000 Biology:Müller S.: 2010.

    21

    G. Sicoli, F. Wachowius, M. Bennati, C. Höbartner*, Secondary Structure Probing of Spin-labeled RNA by Pulsed EPR Spectroscopy. Angew. Chem. Int. Ed. 2010, 49, 6443-6447. Angew. Chem. 2010, 122, 6588-6592.
    SI (* co-corresponding author)

    20

    F. Wachowius, C. Höbartner, Chemical RNA modifications for studies of RNA structure and dynamics. ChemBioChem 2010, 11, 469-480.

    2009

     

    19

    D.A. Heller, H. Jin, B.M. Martinez, D. Patel, B.M. Miller, T.-K. Yeung, P.V. Jena, C. Höbartner, T. Ha, S.K. Silverman, M.S. Strano, Multimodal optical sensing and analyte specificity using single-walled carbon nanotubes. Nat. Nanotechnol. 2009, 4, 114-120. SI

     

    comments by others
    News & views: T.D. Krauss, Nat. Nanotechnol. 2009, 4, 85-86.

    18

    R. Rieder, C. Höbartner, R. Micura, Enzymatic ligation strategies for the preparation of purine riboswitches with site-specific chemical modifications. in Riboswitches (Ed. A. Serganov), Methods Mol. Biol. 2009, 540, 15-24.

    2008

     

    17

    P. I. Pradeepkumar, C. Höbartner, D.A. Baum S. K. Silverman, DNA-catalyzed formation of nucleopeptide linkages.
    Angew. Chem. Int. Ed. 2008, 47, 1753-1757. Angew. Chem. 2008, 120, 1777-1781. SI

    2007

     

    16

    C. Höbartner, S. K. Silverman, Recent Advances in DNA Catalysis.
    Biopolymers 2007, 87, 279-292.

    15

    C. Höbartner, S. K. Silverman, Engineering a Selective Small-Molecule Substrate Binding Site into a Deoxyribozyme. Angew. Chem. Int. Ed. 2007, 46, 7420-7424. Angew. Chem. 2007, 119, 7564-7568. SI

    14

    C. Höbartner, P. I. Pradeepkumar, S. K. Silverman, Site-Selective Depurination by a Periodate-Dependent Deoxyribozyme.
    Chem. Commun. 2007, 2255-2257.

    2006

     

    13

    R. Micura, C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, H. Moroder, Preparation of 2'-Deoxy-2'-Methylseleno-Modified RNA.
    Current Protocols in Nucleic Acid Chemistry 2006, 1.15.1-1.15.34.

    2005

     

    12

    C. Höbartner, S. K. Silverman, Modulation of RNA tertiary folding by incorporation of caged nucleotides.
    Angew. Chem. 2005, 117, 7471-7475; Angew. Chem. Int. Ed. 2005, 44, 7305-7309. SI

    11

    C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, A. Polonskaia, A. Serganov, R. Micura, Syntheses of RNAs with up to 100 nucleotides containing site-specific 2'-Se-methyl labels for use in X-ray crystallography. J. Am. Chem. Soc. 2005, 127, 12035-12045.

    10

    A. Serganov, S. Keiper, L. Malinina, V. Tereshko, E. Skripkin, C. Höbartner, A. Polonskaia, A. T. Phan, R. Wombacher, R. Micura, Z. Dauter, A. Jäschke, D. J. Patel, Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat. Struct. Mol. Biol. 2005, 12, 218-224.

     

    comments by others
    News and views:JN Pitt, A. Ferré-d'Amare, Nat. Struct. Mol. Biol. 2005, 12, 206-208. SI

    2004

     

    9

    A. Serganov, Y. R. Yuan, O. Pikovskaya, A. Polonskaia, L. Malinina, A.T. Phan, C. Höbartner, R. Micura, R.R. Breaker, D.J. Patel, Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs. Chem. Biol. 2004, 11, 1729-1741.

     

    comments by others
    Comment: A. Lescoute, E. Westhof, Chem. Biol. 2005, 12, 10-13.

    8

    C. Höbartner, H. Mittendorfer, K. Breuker, R. Micura, Triggering of RNA secondary structures by a functionalized nucleobase.
    Angew. Chem. 2004, 116, 4012-4015; Angew. Chem. Int. Ed. 2004, 43, 3922-3925. SI

    7

    C. Höbartner, R. Micura, Chemical synthesis of selenium-modified oligoribonucleotides and their enzymatic ligation leading to an U6 snRNA stem-loop segment. J. Am. Chem. Soc. 2004, 126, 1141-1149. SI

    2003

     

    6

    R. Micura and C. Höbartner, On secondary structure rearrangements and equilibria of small RNAs. ChemBioChem 2003, 4, 984-990.

    5

    C. Höbartner, C. Kreutz, E. Flecker, E. Ottenschläger, W. Pils, K. Grubmayr, R. Micura, The synthesis of 2'-O -[(triisopropylsilyl)oxy]methyl (TOM) phosphoramidites of methylated ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for use in automated RNA solid-phase synthesis. Monatshefte für Chemie - Chemical Monthly 2003, 134, 851-873.

    4

    C. Höbartner, R. Micura, Bistable secondary structures of small RNAs and their structural probing by comparative imino proton NMR spectroscopy. J. Mol. Biol. 2003, 325, 421-431.

    2002

     

    3

    C. Höbartner, M.-O. Ebert, B. Jaun, R. Micura, RNA two-state conformation equilibria and the effect of nucleobase methylation. Angew. Chem. 2002, 114, 619-623; Angew. Chem. Int. Ed. 2002, 41, 605-609.

    2001

     

    2

    R. Micura, W. Pils, C. Höbartner, K. Grubmayr, M.-O. Ebert, B. Jaun, Methylation of nucleobases in RNA oligonucleotides mediates hairpin-duplex conversion. Nucleic Acids Res. 2001, 29, 3977-4005.

    2000

     

    1

    Novel fluoride-labile nucleobase-protecting groups for the synthesis of 3'(2')-O -aminoacylated RNA sequences, A. Stutz, C. Höbartner, S. Pitsch; Helv. Chim. Acta 2000, 83, 2477-2503.

    Buchkapitel

    7 F. Javadi-Zarnaghi, C. Höbartner, Strategies for Characterization of Enzymatic Nucleic Acids. In: Advances in Biochemical Engineering/Biotechnology. Springer, Berlin, Heidelberg 2017, 1-22. 

    6

    C. Höbartner, L. Büttner, F. Javadi-Zarnaghi, Bioorthogonal modifications and cycloaddition reactions for RNA Chemical Biology, in RNA Structure and Folding (Eds. D. Klostermeier, C. Hammann). DeGruyter 2013, 75-99. ISBN 978-3110284591

    5

    P.I. Pradeepkumar, C. Höbartner, RNA-Cleaving DNA enzymes and their potential therapeutic applications as antibacterial and antiviral agents, in From Nucleic Acids Sequences to Molecular Medicine (Eds. V. Erdmann, J. Barciszewski), Springer, 2012, 371-410. ISBN 978-3-642-27425-1

    4

    C. Höbartner, P.I. Pradeepkumar, DNA catalysts for synthetic applications in biomolecular chemistry, in New strategies in chemical synthesis and catalysis (Ed. B. Pignataro), Wiley-VCH, 2012, 129-155. ISBN 978-3-527-33090-4

    3

    C. Höbartner, Chemical Synthesis of RNA, in Alternative pre-mRNA splicing: Theory and Protocols (Eds. S. Stamm, C. Smith, R. Lührmann), Wiley-VCH, 2012, 155-163. ISBN 3-527-32606-5

    2

    C. Höbartner, F. Wachowius, Chemical synthesis of modified RNA, in The Chemical Biology of Nucleic Acids (Ed. G. Mayer), Wiley, 2010, 1-37. ISBN: 978-0-470-51974-5

    1

    R. Micura and C. Höbartner, Equilibria of RNA secondary structures, in Highlights in Bioorganic Chemistry, Methods and Applications (Ed. C. Schmuck, H. Wennemers) Wiley-VCH, Weinheim, 2004, 3-16.

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