Intern
    THE SEIBEL GROUP: ORGANIC AND BIOLOGICAL CHEMISTRY

    E. Memmel, J. Seibel
    Zuckersüß und richtig wichtig.
    Nachrichten aus der Chemie 201361, 1207–1211.

    M. Timm, J. Görl, M. Kraus, S. Kralj, H. Hellmuth, R. Beine, K. Buchholz, L. Dijkhuizen, J. Seibel
    An unconventional glycosyl transfer reaction: glucansucrase GTFA functions as an allosyltransferase enzyme.
    ChemBioChem 201314, 2423–2436.

    E. Memmel, A. Homann, T. A. Oelschlaeger, J. Seibel
    Metabolic glycoengineering of Staphylococcus aureus reduces its adherence to human T24 bladder carcinoma cells.
    Chem. Commun. 201349, 7301–7303.

    J. Seibel, S. König, M. Sauer
    Investigating infection processes with a workflow from organic chemistry to biophysics: The combination of metabolic glycoengineering, super-resolution fluorescence imaging and proteomics.
    Expert Review of Proteomics, 201310, 25–31. 

    J. Seibel
    From Gene to Product: Tailor-Made Oligosaccharides and Polysaccharides by Enzyme and Substrate Engineering.
    in Carbohydrate-Modifying Biocatalysts
    by Peter Grunwald (Ed.) Pan Stanford Publishing Pte. Ltd., Singapure (2012), 535–548.

    A. Homann, M. Timm, J. Seibel
    Chemo-enzymatic synthesis and in vitro cytokine profiling of tailor-made oligofructosides.
    BMC Biotechnol. 201212(1), 90.

    J. Görl, M. Timm, J. Seibel
    Mechanism-Oriented Redesign of an Isomaltulose Synthase to an Isomelezitose Synthase by Site-Directed Mutagenesis.
    ChemBioChem 201213, 149–156.

    A. Goehler, N. Bertleff, M. Timm, S. Doose, J. Seibel, M. Sauer
    Super-Resolution dSTORM Imaging of Human Galectin-1 Interacting with Neuroblastoma Cells.
    Biophysical Journal 2012102, 223.

    M. Ortiz-Soto, J. Seibel
    Tailoring Enzymatic Reactions.
    In Proceedings of the International Beilstein Symposium on Glyco-Bioinformatics
    2nd International Beilstein Symposium on Glyco-Bioinformatics
    Cracking the Sugar Code by Navigating the Glycospace 2012, 39–54.

    M. Eppinger, B. Bunk, M. A. Johns, J. N. Edirisinghe, K. K. Kutumbaka, S. S. Koenig, H. H. Creasy, M. J. Rosovitz, D. R. Riley, S. Daugherty, M. Martin, L. D. Elbourne, I. Paulsen, R. Biedendieck, C. Braun, S. Grayburn, S. Dhingra, V. Lukyanchuk, B. Ball, R. Ul-Qamar, J. Seibel, E. Bremer, D. Jahn, J. Ravel, P. S. Vary
    Genome sequences of the biotechnologically important Bacillus megaterium strains QM B1551 and DSM319.
    J Bacteriol. 2011193, 199–213.

    C. P. Strube, A. Homann, M. Gamer, D. Jahn, J. Seibel*, D.W. Heinz
    Polysaccharide synthesis of the levansucrase SacB from Bacillus megaterium is controlled by distinct surface motifs.
    J. Biol. Chem. 2011286, 17593–17600.

    L. Hillringhaus, J. Seibel
    Cracking the Glycocode: Recent Developments in Glycomics.
    in Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life (ed B. Pignataro),
    Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2010.

    L. Hillringhaus, J. Seibel*
    Glycochips.
    in "Encyclopedia of Industrial Biotechnology" (Flickinger, M. C., Ed.) Wiley, 2010.

    K. Buchholz, J. Seibel*
    Industrial applications of carbohydrates.
    in "Encyclopedia of Industrial Biotechnology" (Flickinger, M. C., Ed.) Wiley, 2010.

    J. Seibel*, H. J. Jördening, K. Buchholz
    Extending Synthetic Routes for Oligosaccharides by Enzyme, Substrate and Reaction Engineering.
    Adv Biochem Eng Biotechnol. 2010120, 163–193.

    J. Seibel, K. Buchholz
    Tools in Oligosaccharide Synthesis: Current Research and Application.
    Advances in Carbohydrate Chemistry and Biochemistry, 201063, 101–138.

    A. Homann, R. ul-Qamar, S. Serim, P. Dersch, J. Seibel
    Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.
    Beilstein J. Org. Chem. 20106, 1–7.

    A. Homann, J. Seibel
    Chemo-enzymatic synthesis and functional analysis of natural and modified glycostructures.
    Nat. Prod. Rep. 200926, 1555–1571.

    A. Homann, J. Seibel
    Towards tailor-made oligosaccharides-chemo-enzymatic approaches by enzyme and substrate engineering.
    Appl Microbiol Biotechnol. 200983, 209–216.

    R. Beine, A. Rocas Valente, R. Biedendieck, D. Jahn, J. Seibel
    Directed optimization of biocatalytic transglycosylation processes by the integration of genetic algorithms and fermentative approaches into a kinetic model.
    Process Biochemistry 200944, 1103–1114.

    J. Seibel, L. Hillringhaus
    Glycochips - Dem Zuckercode auf der Spur.
    Labor&more 5/2008

    S. Kralj, K. Buchholz, L. Dijkhuizen, J. Seibel
    Fructansucrase enzymes and sucrose analogues: new approach for the synthesis of unique fructo-oligosaccharides.
    Biocatal. Biotrans 200826, 32–42.

    R. Beine, R. Moraru, M. Nimtz, S. Na'amnieh, A. Pawlowski, K. Buchholz, J. Seibel
    Synthesis of novel fructooligosaccharides by substrate and enzyme engineering.
    J. Biotechnol. 2008138, 33–41.

    K. Buchholz, J. Seibel
    Industrial carbohydrate biotransformations.
    Carbohyr. Res. 2008343(12), 1966–79.

    H. Hellmuth, S. Wittrock, S. Kralj, L. Dijkhuizen, B. Hofer, J. Seibel
    Engineering the Glucansucrase GTFR enzyme reaction- and glycosidic bond specificity: towards tailor-made polymer and oligosaccharide products.
    Biochemistry 200847, 6678–6684.

    A. Zuccaro, S. Götze, S. Kneip, P. Dersch, J. Seibel
    Taylor made fructooligosaccharides by combination of substrate and genetic engineering.
    ChemBioChem 20089, 143–149.

    R. Biedendieck, R. Beine, M. Gamer, E. Jordan, K. Buchholz, J. Seibel, L. Dijkhuizen, M. Malten, D. Jahn
    Export, purification and activities of affinity tagged Lactobacillus reuteri levansucrase produced by Bacillus megaterium.
    Appl Microbiol Biotechnol 200774(5), 1062–1073.

    A. Homann, R. Biedendieck, S. Götze, D. Jahn, J. Seibel
    Insights into polymer versus oligosaccharide synthesis - mutagenesis and mechanistic studies of a novel levansucrase from Bacillus megaterium.
    Biochem J. 2007407, 189–198.

    H. Hellmuth, L. Hillringhaus, S. Höbbel, S. Kralj, L. Dijkhuizen, J. Seibel
    Highly efficient Chemoenzymatic Synthesis of Novel branched Thiooligosaccharides via Substrate Direction using Glucansucrases.
    ChemBioChem 20078, 273–276.

    J. Seibel, H.-J. Jördening, K. Buchholz
    Glycosylation with activated sugars using glycosyltransferases and transglycosidases.
    Biocat. Biotrans. 200624, 311–354.

    J. Seibel, H. Hellmuth, B. Hofer, B. Schmalbruch
    Identification of new donor specificities of Glycosyltransferase R via the aid of substrate microarrays.
    ChemBioChem 20067, 310–320.

    W. Pohl, H. Hellmuth, M. Hilbert, J. Seibel, P. J. Walla
    A two-photon fluorescence correlation study of lectins interacting with carbohydrated 20 nm beads.
    ChemBioChem 20067, 268–274.

    J. Seibel, R. Moraru, S. Götze, S. Na'amnieh, A. Pawlowski, K. Buchholz
    Synthesis of sucrose analogues and the mechanism of action of Bacillus subtilis fructosyltransferase (levansucrase).
    Carbohydr. Res. 2006341, 2335–2349.

    J. Seibel, R. Beine, R. Moraru, C. Behringer, K. Buchholz
    A New Pathway for the Synthesis of Oligosaccharides by the Use of non-Leloir glycosyltransferases.
    Biocat. Biotrans. 200624, 157–165.

    J. Seibel
    Enzymatische Oligosaccharidsynthesen: vom Gen zum Produkt.
    Nachrichten aus der Chemie 20062, 110–114.

    J. Seibel
    Biocatalysis.
    by A. S. Bommarius and B. R. Riebel.
    Chemie Ingenieur Technik (2005), 77(3), 311–312.

    I. E. Baciu, H. J. Jördening, J. Seibel, K. Buchholz
    Investigations of the transfructosylation reaction by fructosyltransferase from B. subtilis NCIMB 11871 for the synthesis of the sucrose analogue galactosyl-fructoside.
    J. Biotechnol. 2005116, 347–357.

    J. Seibel, S. J. Macdonald, C. J. Schofield
    Synthesis of δ-lactam (2-oxopiperazine) inhibitors of elastase.
    Journal Chemical Research 200512, 826–832.

    J. Seibel, R. Moraru, S. Götze
    Biocatalytic and chemical investigations in the synthesis of sucrose analogues.
    Tetrahedron 200561, 7081–7086.

    J. Seibel, L. Hillringhaus, R. Moraru
    Microwave-assisted Glycosylation for the Synthesis of Glycopeptides.
    Carbohydr. Res. 2005340, 507–511.

    K. Buchholz, J. Seibel
    Isomaltooligosaccharides.
    in Oligosaccharides in Food and Agriculture
    Edited by Gillian Eggleston and Gregory L. Coté
    ACS Publication, Oxford University Press, 2003, Washington

    J. Seibel*, K. Buchholz
    Chemoenzymatische Synthese von Oligosacchariden und glykosylierten Naturstoffen.
    Transkript (Sonderheft Nachhaltige Biokatalyse) 20039, 40–41.

    J. Seibel, D. Brown, A. Amour, S. J. Macdonald, N. J. Oldham, C. J. Schofield
    Synthesis and evaluation of delta-Lactams (Piperazones) as elastase inhibitors.
    Bioorg Med Chem Lett. 200313, 387–389.

    J. J. Turnbull, M. J. Nagle, J. Seibel, R. W. Welford, G. H. Grant, C. J. Schofield
    The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity.
    Bioorg Med Chem Lett. 200313, 3853–3857.

    J. M. Elkins, K. S. Hewitson, L. A. McNeill, J. F. Seibel, I. Schlemminger, C. W. Pugh, P. J. Ratcliffe, C. J. Schofield
    Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
    J. Biol. Chem. 2003278, 1802–1806.

    L. A. McNeill, K. S. Hewitson, T. D. Claridge, J. F. Seibel, L. E. Horsfall, C. J. Schofield
    Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
    Biochem. J. 2002367, 571–575.

    L. F. Tietze, J. Seibel, F. Djalali Bazzaz, J. Görlitzer, J. H. Peters
    Monoclonal Antibody against Vitamin E.
    Immunobiology 1999200, 713.

    Encyclopedia

    ROEMPP Online, section carbohydrates

    Patents

    Method for synthesizing oligosaccharides and glycosylation.
    J. Seibel, H.-J. Jördening, K. Buchholz, R. Beine
    PCT/EP 2006/060932 (2006)

    Method for selecting catalytic antibodies.
    L. F. Tietze, J. Seibel, F. Djalali Bazzaz, J. H. Peters
    WO0028330.

    Catalytic antibodies and method for producing chromanes by cyclization with said antibodies.
    L. F. Tietze, J. Seibel, F. Djalali Bazzaz, J. H. Peters
    WO0028063.

    Antibodies, mini-antibodies or antibody fragments binding to vitamin E and the use thereof.
    L. F. Tietze, J. Seibel, F. Djalali Bazzaz, J. H. Peters
    WO0027884.

    Kontakt

    Professur für Organische Chemie am Institut für Organische Chemie
    Am Hubland
    97074 Würzburg

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