Current Research Topics

• Synthesis of simplified bioactive N,C-coupled naphthylisoquinolines and arylpyridinium salts
• Investigations on the biosynthesis of naphthylisoquinoline alkaloids (joint project with A. Irmer)

PhD Thesis

Since 10/2007 at the Institute of Organic Chemistry, University of Würzburg, in the working group of Prof. Dr. Dr. h.c. G. Bringmann.

Diploma Thesis

"Synthesis of biologically active isoquinolinium salts with an N,C-biaryl axis"

Publications

Fenton‘s oxidation: a tool for the investigation of potential drug metabolites, E. Kugelmann, C.R. Albert, G. Bringmann, U. Holzgrabe, J. Pharm. Biomed. Anal. 2011, published online, DOI:10.1016/j.jpba.2010.12.016.

The Final Steps of Bacillaene Biosynthesis in Bacillus amyloliquefaciens FZB42: Direct Evidence for beta,gamma-Dehydration by a trans- AT Polyketide Synthase and Identification of the True Biosynthetic End Product, J. Moldenhauer, D.C.G. Götz, C.R. Albert, S.K. Bischof, K. Schneider, R.D. Süssmuth, M. Engeser, H. Gross, G. Bringmann, J. Piel, Angew. Chem. 2010, 122, 1507 - 1509.

Poster

"Structural Improvement and Mode of Action of Antiplasmodial Naphthylisoquinoline Alkaloids“,
M. Diegel, C. R. Albert, S. K. Bischof, M. Mikyna, S. Müller, G. Bringmann, 3. Joint Ph.D. students meeting of the collaborative research centers SFB 630 & 544, June 2007, Zellingen/Retzbach, Germany.

"Naphthylisoquinoline Alkaloids: Synthesis of Hybrids, Simplified Analogs, and Photoactivatable Derivatives for Target Screening“
M. Mikyna, C. R. Albert, S. K. Bischof, M. Diegel, S. Müller, G. Bringmann, ChemSyStM December 2007, Würzburg, Germany.

"Naphthylisoquinoline Alkaloids: Biosynthetic Origin",
A. Irmer, S. Rüdenauer, J. Muttanyatta-Comar, C. R. Albert, T. F. Noll, G. Bringmann, ChemSyStM, December 2007, Würzburg, Germany.

"Investigations on the Mode of Action of N,C-coupled naphthylisoquinoline Alkaloids in Leishmania major",
U. Schurigt, C. R. Albert, A. Ponte-Sucre, T. Gulder, G. Bringmann, H. Moll, 4. Joint Ph. D. students meeting of the collaborative research centers SFB 630, 544 & 766, November 2008, Bronnbach, Germany.

"N,C-coupled naphthylisoquinolines: Investigations on their Possible Modes of Action in Leishmania major",
C. R. Albert, U. Schurigt, A. Ponte-Sucre, T. Gulder, H. Moll, G. Bringmann, ChemSyStM, December 2008, Würzburg, Germany.

"C,C- and N,C-Coupled Naphthylisoquinolines: Synthesis of Simplified Analogs with Better and More Specific Antiplasmodial Activities",
C. Albert, S. Bischof, B. Breitenbücher, T. Gulder, S. Müller, R. Brun, G.
Bringmann, Synthesefest LMU München 2009, München, Germany.

"Mitochondrial Complex I and Topoisomerase II as Target of Leishmanicidal N,C-Coupled Naphthylisoquinoline Alkaloids", C. R. Albert, U. Schurigt, C. Glowa, M. Schultheis, G. Bringmann, H. Moll, 2th International Symposium of the Collaborative Research Center 630, October 2009, Würzburg, Germany. (GSLS Poster Award)

"Leishmanicidal N,C-Coupled Naphthylisoquinoline: Interaction with the Mitochondrial Respiratory Chain and Modulation of the DNA Topoisomerase II Activity", 5th Joint Ph.D. students meeting of the collaborative research centers SFB 630, 544 & 766, November 2009, Heidelberg, Germany.

"Anti-infective Naphthylisoquinolines: Total Synthesis and Preparation of Simplified Bioactive Analogs", C. R. Albert, S. K. Bischof, Y. Hemberger, B. Hertlein-Amslinger, R. Brun, G. Bringmann, 5th Summer School Medicinal Chemistry, September 2010, Regensburg, Germany.

"Anti-infective Naphthylisoquinolines: Preparation of Simplified Bioactive Analogs and (Q)SAR Studies", C. R. Albert, S. K. Bischof, R. Brun, G. Bringmann, ChemSyStM, December 2010, Würzburg, Germany. (Poster-Award)

Lectures

C. R. Albert; Naphthylisoquinoline Alkaloids as Promising Anti-Infective Lead Structures: Synthesis of Simplified Analogs and Optimization of the Biological Activities; June 2009, Würzburg, Germany.

C. R. Albert, "Caught in the Act: The Final Intermediates in Bacillaene Biosynthesis Elucidated by LC-NMR", 39th Natural Products Meeting, April 2010, Jena, Germany.