Current Research Topics

• QSAR-guided synthesis of simplified bioactive naphthylquinoline and naphthylisoquinoline analogs

PhD Thesis

Since 02/2008 at the Institute of Organic Chemistry, University of Würzburg, in the working group of Prof. Dr. Dr. h.c. G. Bringmann.

Diploma Thesis

"QSAR-guided synthesis of antiplasmodial, simplified naphthylisoquinoline derivatives"

Publications

QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids,G. Bringmann, S. K. Bischof, S. Müller, T. Gulder, C. Winter, A. Stich, H. Moll, M. Kaiser, R. Brun, J. Dreher, K. Baumann, Eur. J. Med. Chem. 2010, 45,  5370-5383.

Very-long chain aldehydes promote in vitro prepenetration processes of Blumeria graminis in a dose and chain-length dependent manner, A. Hansjakob, S. Bischof, G. Bringmann, M. Riederer, U. Hildebrand New Phytologist, 2010, 188, 1039-1054. 

The Final Steps of Bacillaene Biosynthesis in Bacillus amyloliquefaciens FZB42: Direct Evidence for beta,gamma-Dehydration by a trans- AT Polyketide Synthase and Identification of the True Biosynthetic End Product, J. Moldenhauer, D.C.G. Götz, C.R. Albert, S.K. Bischof, K. Schneider, R.D. Süssmuth, M. Engeser, H. Gross, G. Bringmann, J. Piel, Angew. Chem. 2010, 122, 1507 - 1509.

Earlier Research Experience

March 2005 - July 2005

Internship in the working group of Dr. P. W. Dyer, Institute of Inorganic Chemistry at the University of Durham (UK)

Topic: "Di(oxo)- and bis(imido)-molydenum(VI) complexes with bidentate chelate ligands"

March 2006 - April 2006

Internship in the group of Prof. Dr. Dr. h.c. G. Bringmann, Institute of Organic Chemistry at the University of Würzburg

Topic: "Synthesis of hydroxylated Xanthones"

Poster

"Structural Improvement and Mode of Action of Antiplasmodial Naphthylisoquinoline Alkaloids“,
M. Diegel, C. R. Albert, S. K. Bischof, M. Mikyna, S. Müller, G. Bringmann, 3. Joint Ph.D. students meeting of the collaborative research centers SFB 630 & 544, June 2007, Zellingen/Retzbach, Germany.

"Naphthylisoquinoline Alkaloids: Synthesis of Hybrids, Simplified Analogs, and Photoactivatable Derivatives for Target Screening“
M. Mikyna, C. R. Albert, S. K. Bischof, M. Diegel, S. Müller, G. Bringmann, ChemSyStM December 2007, Würzburg, Germany.

"Antiplasmodial Naphthylisoquinolines: Synthesis of Simplified Analogs and Investigations on the Mode of Action“
S. K. Bischof, M. Mikyna, S. Müller, R. Brun, C. Gelhaus, M. Leippe, G. Bringmann, ChemSyStM December 2008, Würzburg, Germany.

"C,C- and N,C-Coupled Naphthylisoquinolines: Synthesis of Simplified Analogs with Better and More Specific Antiplasmodial Activities"

C. Albert, S. Bischof, B. Breitenbücher, T. Gulder, S. Müller, R. Brun, G. Bringmann, Synthesefest LMU München 2009, München, Germany.

"Anti-infective Naphthylisoquinolines: Total Synthesis and Preparation of Simplified Bioactive Analogs", C. R. Albert, S. K. Bischof, Y. Hemberger, B. Hertlein-Amslinger, R. Brun, G. Bringmann, 5th Summer School Medicinal Chemistry, September 2010, Regensburg, Germany.

"Anti-infective Naphthylisoquinolines: Preparation of Simplified Bioactive Analogs and (Q)SAR Studies", C. R. Albert, S. K. Bischof, R. Brun, G. Bringmann, ChemSyStM, December 2010, Würzburg, Germany. (Poster-Award)

Lectures

S. K. Bischof, M. Mikyna, Antiplasmodial Naphthylisoquinolines: Synthesis of Simplified Analogs andInvestigations on the Mode of Action, 4. Joint Ph.D. students meeting of the collaborative research centers SFB 630, 544 & 766, November 2008, Bronnbach, Germany.