Curriculum vitae

Selected Awards and Honors

Research Topics

General Research Topics: Organic Chemistry – Natural Products Chemistry with analytical, synthetic, biochemical, pharmaceutical, and computational facets.

Selected Fields of Research: Mono- and dimeric naphthyl isoquinoline alkaloids: isolation from Ancistrocladaceae and Dioncophyllaceae plants, structural elucidation, partial and total synthesis, cultivation of plants and plant cell cultures, establishment of novel biosynthetic pathways to quinoline and isoquinoline alkaloids. – Spectroscopically (LC-NMR, LC-MS, LC-CD) and bioassay-guided search for new bioactive compounds from tropical medical plants (i.a. antiplasmodial, antitrypanosomal, antileishmanial, anti-Candida, anti-biofilm, and antitumoral). – Glucosinolates: analytics, transport, signal function and metabolism. – Novel concepts for the regio- and stereoselective synthesis of biaryls, e.g. by the atropo-selective cleavage of biaryl lactones: mechanistical studies and application to the total synthesis of chiral biaryls: bioactive compounds (i.a. phenyl anthraquinones, dimeric carbazol alkaloids, dimeric sesquiterpenes and vancomycin analogs) and tools for asymmetric synthesis (ligands, catalysts). – Novel aspects of porphyrin chemistry (i.a. chiral di- and triporphyrins). - Computational chemistry: calculation of structures, dynamics, chemical reactivities, spectral properties (i.a. CD spectra), and bioactivities of molecules (i.a. QSAR investigations).

Grant Projects (here only within Networks):

Synergistic Activities

Memberships

• i.a. Gesellschaft Deutscher Chemiker e.V., American Chemical Society, Gesellschaft für Arzneipflanzenforschung e.V., Arbeitsgemeinschaft Deutscher Universitätsprofessoren für Chemie (ADUC), Liebig-Vereinigung für Organische Chemie.
• Vice Chairman of the DECHEMA-Working Committee "Low-Molecular Bioactive Compounds"; since 1990 Member of the Program Committee of the Annual Irsee Natural Products Meetings ("Irseer Naturstofftage"), since 2002 Chairman.
• Member of the Directory Panel of the Interdisciplinary Center for Addiction Research in Würzburg (IZSW), of the Rudolf-Virchow Center (DFG Research Center for Experimental Biomedicine), and of the ZINF (Center for Infectious Disease Research) of the University of Würzburg.

Further Selected Activities

• Initiator of the Mini-Symposia "Natural Products: Chemistry, Biology, and Ecology": Natural Products Chemistry Workshops for PhD students, since 1991 regularly twice per year, involving the Universities of Bayreuth, Leipzig, Bonn, and Vienna, the Leibniz Institute for Plant Biochemistry in Halle, the Max-Planck Institute (MPI) for Chemical Ecology in Jena, and the Leibniz Institute for Natural Product Research and Infection Biology (HKI) in Jena.
• Initiator of official university cooperations with the Université de Kinshasa (UNIKIN) and the Université Catholique du Graben (UCG) in Butembo (République Démocratique du Congo), and with the University of Nairobi (Kenya); Head of the NGO “Support for the University of Kinshasa” (“Förderverein Uni Kinshasa”).

Reviewer for Funding Agencies

National and international evaluation panels, i.a., for the evaluation of research networks (SFBs, etc.), research institutes (e.g., ICSN in Gif-sur-Yvette and the IPB in Halle), of program-associated research proposals (e.g., within the French VIHPAL programme, for the Danish Council for Development Research or as an EU reviewer), as a member of the DAAD Election Committee Africa, etc..

Work and Membership in University Committees

• Standing Committee of the University for Strategic Plannings (since 1991)
• Senate of the University (2001-2004, and since 2009)
• University Council (since 2009).

Twelve (from a Total of ca. 630) Selected Publications from the Major Fields of Research

1. G. Bringmann, T. Gulder, B. Hertlein, Y. Hemberger, F. Meyer
   J. Am. Chem. Soc. 2010, 132, 1151-1158
   Total Synthesis of the N,C-Coupled Naphthylisoquinoline Alkaloids Ancistrocladinium A and B and Related Analogues.

2. M. Xu, T. Bruhn, B. Hertlein, R. Brun, A. Stich, J. Wu, G. Bringmann
   Chem. Eur. J. 2010, 16, 4208-4216 (with cover picture)
   Shuangancistrotectorines A-E, Dimeric Naphthylisoquinoline Alkaloids with Three Chiral Biaryl Axes, from the Chinese Plant Ancistrocladus tectorius.

3. D.C.G. Götz, T. Bruhn, M.O. Senge, G. Bringmann
   J. Org. Chem. 2009, 74, 8005-8020 (with cover picture)
   Synthesis and Stereochemistry of Highly Unsymmetric ß,meso-linked Porphyrin Arrays.

4. G. Bringmann, T. Bruhn, K. Maksimenka, Y. Hemberger
   Eur. J. Org. Chem. 2009, 2717-2727
   The Assignment of Absolute Stereostructures through Quantum Chemical Circular Dichroism Calculations.

5. A. Ponte-Sucre, T. Gulder, A. Wegehaupt, C. Albert, C. Rikanovic, L. Schäflein, A. Frank, M. Schultheis, M. Unger, U. Holzgrabe, G. Bringmann, H. Moll
   J. Med. Chem. 2009, 52, 626-636
   Structure-Activity Relationship and Studies on the Molecular Mechanism of Leishmanicidal N,C-Coupled Arylisoquinolinium Salts.

6. G. Bringmann, D.C.G. Götz, T.A.M. Gulder, T.H. Gehrke, T. Bruhn, T. Kupfer, R. Radacki, H. Braunschweig, A. Heckmann, C. Lambert
   J. Am. Chem. Soc. 2008, 130, 17812-17825
   Axially Chiral ß,ß‘-Bisporphyrins: Synthesis and Configurational Stability Tuned by the Central Metals.

7. G. Bringmann, T.A.M. Gulder, M. Reichert, T. Gulder
   Chirality 2008, 20, 628-642
   The Online Assignment of the Absolute Configuration of Natural Products: HPLC-CD in Combination with Quantum Chemical CD Calculations.
   

8. G. Bringmann, J. Mutanyatta-Comar, M. Knauer, B.M. Abegaz
   Nat. Prod. Rep. 2008, 25, 696-718
   Knipholone and Related 4-Phenylanthraquinones: Structurally, Pharmacologically, and Biosynthetically Remarkable Natural Products.

9. G. Bringmann, T.F. Noll, T. Gulder, M. Dreyer, M. Grüne, D. Moskau
   J. Org. Chem. 2007, 72, 3247-3252
   Polyketide Folding in Higher Plants: Biosynthesis of the Phenylanthraquinone Knipholone.

10. G. Bringmann, T.F. Noll, T.A.M. Gulder, M. Grüne, M. Dreyer, C. Wilde, F. Pankewitz, M. Hilker, G.D. Payne, A.L. Jones, M. Goodfellow, H.-P. Fiedler
    Nature Chem. Biol. 2006, 2, 429-433
    Different Polyketide Folding Modes Converge to an Identical Molecular Architecture.

11. G. Bringmann, I. Kajahn, M. Reichert, S.E.H. Pedersen, J.H. Faber, T. Gulder, R. Brun, S.B. Christensen, A. Ponte-Sucre, H. Moll, G. Heubl, V. Mudogo
    J. Org. Chem. 2006, 71, 9348-9356
    Ancistrocladinium A and B, the First N,C-Coupled Naphthyldihydroisoquinoline Alkaloids, from a Congolese Ancistrocladus Species.

12. G. Bringmann, A.J. Price Mortimer, P.A. Keller, M.J. Gresser, J. Garner, M. Breuning
    Angew. Chem. 2005, 117, 5518-5563; Angew. Chem. Int. Ed. 2005, 44, 5384-5427
    Atroposelective Synthesis of Axially Chiral Biaryl Compounds.