Prof. Dr. Dr. h.c. Gerhard Bringmann
Lehrstuhl für Organische Chemie I
Am Hubland
97074 Würzburg
Tel.: +49 931 31 85323
Fax: +49 931 318 4755
Email: bringman@chemie.uni-wuerzburg.de
Secretary's Office:
Anette Zillenbiller
Institut für Organische Chemie
Am Hubland
97074 Würzburg
Tel.: +49 931 31 85322
Curriculum vitae
26.08.1951 | Born in Münster/Germany |
from 1970 | Study of Chemistry at the Universities of Gießen and Münster |
Sept. 1975 | Diploma in Chemistry, diploma thesis with Prof. Dr. B. Franck |
April 1977 | Additional basic studies in Biology ("Vordiplom") |
Jan. 1978 | PhD (Porphyrin Chemistry), with Prof. Dr. B. Franck |
1978 | Research and teaching assistant professor in Münster |
from Oct. 1978 | Post-doc with Prof. Sir D.H.R. Barton at the "Institut de Chimie des Substances Naturelles" of the C.N.R.S. in Gif-sur-Yvette, France |
from Oct. 1979 | Own research and teaching activities at the University of Münster |
June 1984 | Habilitation, Venia legendi for Organic Chemistry |
1986/87 | Chairs offered from the Universities of Vienna and Würzburg |
since Nov. 1987 | Full professor of Organic Chemistry, University of Würzburg (Chair I) |
1998 | Position offered as a director at the Gottfried-Wilhelm-Leibniz Institute for Plant Biochemistry in Halle/Saale (turned down) |
2000-2004 | Dean / Vice Dean of the Faculty of Chemistry and Pharmacy |
2002-2006 | Liaison Professor ("Vertrauensdozent") of the Fonds der Chemischen Industrie for the University of Würzburg |
since July 2003 | Coordinator of the SFB 630 "Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases" |
2003-2009 | Liaison Professor of the DFG (German Research Foundation) for the University of Würzburg |
2005 | Guest Professor, École Supérieure de Chimie Physique Électronique, Lyon (CPE Lyon) |
2005, 2006 | Guest Professor, University of Kinshasa, Democratic Republic of Congo |
2006-2009 | Inaugural Speaker of the ‘Africa Circle’ at the University of Würzburg |
since 2008 | Initiator and Head of an Excellence Scholarship Program (BEBUK) for the Support of the Université de Kinshasa (UNIKIN) and the Université Catholique du Graben (UCG) in Butembo (DR Congo) |
Selected Awards and Honors
1988 | Otto-Klung Award 1988 for Chemistry |
1999 | Prize for Good Teaching, Free State of Bavaria |
2000 | JSPS Invitation Fellowship for Research in Japan |
2000 | Eli Lilly Research Laboratories Lecturer |
2006 | Adolf-Windaus Lecture and Medal |
2006 | Doctor honoris causa, University of Kinshasa, Democratic Republic of Congo |
2007 | Paul-J.-Scheuer Award for Marine Biotechnology (together with J.F. Imhoff and W.E.G. Müller) |
2008 | Honorary Guest Professor, Peking University, Beijing, China |
Research Topics
General Research Topics: Organic Chemistry – Natural Products Chemistry with analytical, synthetic, biochemical, pharmaceutical, and computational facets.
Selected Fields of Research: Mono- and dimeric naphthyl isoquinoline alkaloids: isolation from Ancistrocladaceae and Dioncophyllaceae plants, structural elucidation, partial and total synthesis, cultivation of plants and plant cell cultures, establishment of novel biosynthetic pathways to quinoline and isoquinoline alkaloids. – Spectroscopically (LC-NMR, LC-MS, LC-CD) and bioassay-guided search for new bioactive compounds from tropical medical plants (i.a. antiplasmodial, antitrypanosomal, antileishmanial, anti-Candida, anti-biofilm, and antitumoral). – Glucosinolates: analytics, transport, signal function and metabolism. – Novel concepts for the regio- and stereoselective synthesis of biaryls, e.g. by the atropo-selective cleavage of biaryl lactones: mechanistical studies and application to the total synthesis of chiral biaryls: bioactive compounds (i.a. phenyl anthraquinones, dimeric carbazol alkaloids, dimeric sesquiterpenes and vancomycin analogs) and tools for asymmetric synthesis (ligands, catalysts). – Novel aspects of porphyrin chemistry (i.a. chiral di- and triporphyrins). - Computational chemistry: calculation of structures, dynamics, chemical reactivities, spectral properties (i.a. CD spectra), and bioactivities of molecules (i.a. QSAR investigations).
Grant Projects (here only within Networks):
1990-2001 | Sonderforschungsbereich (Collaborative Research Centre) SFB 347 'Selective Reactions of Metal-Activated Molecules', project leader | |
1992-1998 | BMBF Research Network 'Neurotoxins and Neuroprotection: Importance of Radical Mechanisms and of the Inhibition of the Respiratory Chain for the Etiology of the Parkinsonian Syndrome, of Neurodegenerative, and Ageing Processes', project leader | |
1992-2002 | Graduiertenkolleg (Research Training Group) GRK 64 'Nuclear Magnetic Resonance in vivo and in vitro for Biological and Medicinal Basic Research', project leader | |
1994-2000 | Sonderforschungsbereich (Collaborative Research Centre) SFB 251 'Ecology, Physiology, and Biochemistry of Plants and Animals under Stress', project leader | |
1994-2000 | BMBF-BASF Research Network 'Molecular Interaction between Targets and Natural Products as a Tool for the Identification of New Agents and Agent Models for Agrochemical and Pharmaceutical Research', project leader | |
1994-2000 | WHO Research Network 'Investigation of the Preclinical Potential of Naphthylisoquinoline Alkaloids as a New Category of Antimalarial Drugs', project leader | |
1999-2001 | BMBF-Zentaris Research Network 'Biologically Active Natural Products from Marine Sponges and Associated Microorganisms', project leader | |
2001-2004 |
| |
2001-2008 | BMBF Research Network (Center of Excellence) „Molecular Biotechnology and Bioactive Compounds of Marine Sponges and Sponge-Associated Microorganisms“, project leader | |
2003-2009 | DFG-Schwerpunktprogramm (Priority Programme) SPP 1152 „Evolution of Metabolic Diversity“, project leader | |
since 2003 | Sonderforschungsbereich (Collaborative Research Centre) SFB 630 ''Recognition, Preparation, and Functional Analysis of Agents against Infectious Diseases', coordinator and project leader | |
since 2004 | Sonderforschungsbereich (Collaborative Research Centre) SFB 567, 'Mechanism of Interspecific Interactions of Organisms', project co-leader | |
since 2009 | Klinische Forschergruppe (Clinical Research Unit) KFO 216 „Characterization of the Oncogenic Signaling Network in Multiple Myeloma: Development of Targeted Therapies”, project leader |
Synergistic Activities
Memberships
- i.a. Gesellschaft Deutscher Chemiker e.V., American Chemical Society, Gesellschaft für Arzneipflanzenforschung e.V., Arbeitsgemeinschaft Deutscher Universitätsprofessoren für Chemie (ADUC), Liebig-Vereinigung für Organische Chemie.
- Vice Chairman of the DECHEMA-Working Committee "Low-Molecular Bioactive Compounds"; since 1990 Member of the Program Committee of the Annual Irsee Natural Products Meetings ("Irseer Naturstofftage"), since 2002 Chairman.
- Member of the Directory Panel of the Interdisciplinary Center for Addiction Research in Würzburg (IZSW), of the Rudolf-Virchow Center (DFG Research Center for Experimental Biomedicine), and of the ZINF (Center for Infectious Disease Research) of the University of Würzburg.
Further Selected Activities
- Initiator of the Mini-Symposia "Natural Products: Chemistry, Biology, and Ecology": Natural Products Chemistry Workshops for PhD students, since 1991 regularly twice per year, involving the Universities of Bayreuth, Leipzig, Bonn, and Vienna, the Leibniz Institute for Plant Biochemistry in Halle, the Max-Planck Institute (MPI) for Chemical Ecology in Jena, and the Leibniz Institute for Natural Product Research and Infection Biology (HKI) in Jena.
- Initiator of official university cooperations with the Université de Kinshasa (UNIKIN) and the Université Catholique du Graben (UCG) in Butembo (République Démocratique du Congo), and with the University of Nairobi (Kenya); Head of the NGO “Support for the University of Kinshasa” (“Förderverein Uni Kinshasa”).
Reviewer for Funding Agencies
National and international evaluation panels, i.a., for the evaluation of research networks (SFBs, etc.), research institutes (e.g., ICSN in Gif-sur-Yvette and the IPB in Halle), of program-associated research proposals (e.g., within the French VIHPAL programme, for the Danish Council for Development Research or as an EU reviewer), as a member of the DAAD Election Committee Africa, etc..
Work and Membership in University Committees
- Standing Committee of the University for Strategic Plannings (since 1991)
- Senate of the University (2001-2004, and since 2009)
- University Council (since 2009).
Twelve (from a Total of ca. 630) Selected Publications from the Major Fields of Research
- G. Bringmann, T. Gulder, B. Hertlein, Y. Hemberger, F. Meyer
J. Am. Chem. Soc. 2010, 132, 1151-1158
Total Synthesis of the N,C-Coupled Naphthylisoquinoline Alkaloids Ancistrocladinium A and B and Related Analogues. - M. Xu, T. Bruhn, B. Hertlein, R. Brun, A. Stich, J. Wu, G. Bringmann
Chem. Eur. J. 2010, 16, 4208-4216 (with cover picture)
Shuangancistrotectorines A-E, Dimeric Naphthylisoquinoline Alkaloids with Three Chiral Biaryl Axes, from the Chinese Plant Ancistrocladus tectorius. - D.C.G. Götz, T. Bruhn, M.O. Senge, G. Bringmann
J. Org. Chem. 2009, 74, 8005-8020 (with cover picture)
Synthesis and Stereochemistry of Highly Unsymmetric ß,meso-linked Porphyrin Arrays. - G. Bringmann, T. Bruhn, K. Maksimenka, Y. Hemberger
Eur. J. Org. Chem. 2009, 2717-2727
The Assignment of Absolute Stereostructures through Quantum Chemical Circular Dichroism Calculations. - A. Ponte-Sucre, T. Gulder, A. Wegehaupt, C. Albert, C. Rikanovic, L. Schäflein, A. Frank, M. Schultheis, M. Unger, U. Holzgrabe, G. Bringmann, H. Moll
J. Med. Chem. 2009, 52, 626-636
Structure-Activity Relationship and Studies on the Molecular Mechanism of Leishmanicidal N,C-Coupled Arylisoquinolinium Salts. - G. Bringmann, D.C.G. Götz, T.A.M. Gulder, T.H. Gehrke, T. Bruhn, T. Kupfer, R. Radacki, H. Braunschweig, A. Heckmann, C. Lambert
J. Am. Chem. Soc. 2008, 130, 17812-17825
Axially Chiral ß,ß‘-Bisporphyrins: Synthesis and Configurational Stability Tuned by the Central Metals. - G. Bringmann, T.A.M. Gulder, M. Reichert, T. Gulder
Chirality 2008, 20, 628-642
The Online Assignment of the Absolute Configuration of Natural Products: HPLC-CD in Combination with Quantum Chemical CD Calculations. - G. Bringmann, J. Mutanyatta-Comar, M. Knauer, B.M. Abegaz
Nat. Prod. Rep. 2008, 25, 696-718
Knipholone and Related 4-Phenylanthraquinones: Structurally, Pharmacologically, and Biosynthetically Remarkable Natural Products. - G. Bringmann, T.F. Noll, T. Gulder, M. Dreyer, M. Grüne, D. Moskau
J. Org. Chem. 2007, 72, 3247-3252
Polyketide Folding in Higher Plants: Biosynthesis of the Phenylanthraquinone Knipholone. - G. Bringmann, T.F. Noll, T.A.M. Gulder, M. Grüne, M. Dreyer, C. Wilde, F. Pankewitz, M. Hilker, G.D. Payne, A.L. Jones, M. Goodfellow, H.-P. Fiedler
Nature Chem. Biol. 2006, 2, 429-433
Different Polyketide Folding Modes Converge to an Identical Molecular Architecture. - G. Bringmann, I. Kajahn, M. Reichert, S.E.H. Pedersen, J.H. Faber, T. Gulder, R. Brun, S.B. Christensen, A. Ponte-Sucre, H. Moll, G. Heubl, V. Mudogo
J. Org. Chem. 2006, 71, 9348-9356
Ancistrocladinium A and B, the First N,C-Coupled Naphthyldihydroisoquinoline Alkaloids, from a Congolese Ancistrocladus Species. - G. Bringmann, A.J. Price Mortimer, P.A. Keller, M.J. Gresser, J. Garner, M. Breuning
Angew. Chem. 2005, 117, 5518-5563; Angew. Chem. Int. Ed. 2005, 44, 5384-5427
Atroposelective Synthesis of Axially Chiral Biaryl Compounds.