Publications
2011
Genome Sequences of the Biotechnologically Important Bacillus megaterium Strains QM B1551 and DSM319.
J. Bacteriol. 2011, 193, 4199-4213.
Eppinger M, Bunk B, Johns MA, Edirisinghe JN, Kutumbaka KK, Koenig SS, Huot Creasy H, Rosovitz MJ, Riley DR, Daugherty S, Martin M, Elbourne LD, Paulsen I, Biedendieck R, Braun C, Grayburn S, Dhingra S, Lukyanchuk V, Ball B, Ul-Qamar R, Seibel J, Bremer E, Jahn D, Ravel J, Vary PS.
Polysaccharide synthesis of the levansucrase SacB from Bacillus megaterium is controlled by distinct surface motifs.
J. Biol. Chem. 2011, 286,17593-17600.
C.P. Strube, A. Homann, M. Gamer, D. Jahn, J. Seibel, D.W. Heinz
2010
Glycochips
in "Encyclopedia of Industrial Biotechnology" (Flickinger, M. C., Ed.) Wiley, 2010.
L. Hillringhaus, J. Seibel*
Industrial applications of carbohydrates
in "Encyclopedia of Industrial Biotechnology" (Flickinger, M. C., Ed.) Wiley, 2010.
K. Buchholz, J. Seibel*
Cracking the glycocode
in "Ideas in Chemistry and Molecular Sciences" (Pignataro, B., Ed.) Wiley, 2010.
L. Hillringhaus, J. Seibel*
Extending Synthetic Routes for Oligosaccharides by Enzyme, Substrate and Reaction Engineering.
Adv Biochem Eng Biotechnol. 2010, 120, 163-193.
J. Seibel*, HJ. Jördening, K. Buchholz
Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.
Beilstein J. Org. Chem. 2010, 6, 1-7.
A. Homann, R. ul-Qamar, S. Serim, P. Dersch, J. Seibel*
2009
Chemo-enzymatic synthesis and functional analysis of natural and modified glycostructures.
Nat. Prod. Rep. 2009, 26, 1555-1571.
A. Homann, J. Seibel*
Directed optimization of biocatalytic transglycosylation processes by the integration of genetic algorithms and fermentative approaches into a kinetic model.
Process Biochemistry 2009, 44, 1103-1114.
R. Beine, A. Rocas Valente, R. Biedendieck, D. Jahn, J. Seibel*
Towards tailor-made oligosaccharides-chemo-enzymatic approaches by enzyme and substrate engineering.
Appl Microbiol Biotechnol. 2009, 83, 209-216.
A. Homann, J. Seibel*
2008
Synthesis of novel fructooligosaccharides by substrate and enzyme engineering
J. Biotechnol. 2008, 138, 33-41.
R. Beine, R. Moraru, M. Nimtz, S. Na’amnieh, A. Pawlowski, K. Buchholz, J. Seibel*
Industrial carbohydrate biotransformations
Carbohyr. Res. 2008, 343(12), 1966-79.
K. Buchholz, J. Seibel*
Engineering the Glucansucrase GTFR enzyme reaction- and glycosidic bond specificity: towards tailor-made polymer and oligosaccharide products
Biochemistry 2008, 47, 6678–6684.
H. Hellmuth, S. Wittrock, S. Kralj, L. Dijkhuizen, B. Hofer, J. Seibel*
Taylor made fructooligosaccharides by combination of substrate and genetic engineering
ChemBioChem 2008, 9, 143-149.
A. Zuccaro, S. Götze, S. Kneip, P. Dersch, J. Seibel*
Fructansucrase enzymes and sucrose analogues: new approach for the synthesis of unique fructo-oligosaccharides.
Biocatal. Biotrans 2008, 26, 32-42.
S. Kralj, K. Buchholz, L. Dijkhuizen, J. Seibel*
2007
Insights into polymer versus oligosaccharide synthesis - mutagenesis and mechanistic studies of a novel levansucrase from Bacillus megaterium.
Biochem J. 2007, 407, 189–198.
A. Homann, R. Biedendieck, S. Götze, D. Jahn, J. Seibel*
Highly efficient Chemoenzymatic Synthesis of Novel branched Thiooligosaccharides via Substrate Direction using Glucansucrases.
ChemBioChem 2007, 8, 273-276.
H. Hellmuth, L. Hillringhaus, S. Höbbel, S. Kralj, L. Dijkhuizen, J. Seibel*
Export, purification and activities of affinity tagged Lactobacillus reuteri levansucrase produced by Bacillus megaterium.
Appl Microbiol Biotechnol 2007, 74(5), 1062-1073.
R. Biedendieck, R. Beine, M. Gamer, E. Jordan, K. Buchholz, J. Seibel, L. Dijkhuizen, M. Malten, D. Jahn*
2006
Glycosylation with activated sugars using glycosyltransferases and transglycosidases
Biocat. Biotrans. 2006, 24, 311-354.
J. Seibel*, H.-J. Jördening, K. Buchholz.
Identification of new donor specificities of Glycosyltransferase R via the aid of substrate microarrays
ChemBioChem 2006, 7, 310-320.
J. Seibel*, H. Hellmuth, B. Hofer, B. Schmalbruch.
A two-photon fluorescence correlation study of lectins interacting with carbohydrated 20 nm beads
ChemBioChem 2006, 7, 268-274.
W. Pohl, H. Hellmuth, M. Hilbert, J. Seibel, P. J. Walla*.
Synthesis of sucrose analogues and the mechanism of action of Bacillus subtilis fructosyltransferase (levansucrase).
Carbohydr. Res. 2006, 341, 2335-2349.
J. Seibel*, R. Moraru, S. Götze, S. Na’amnieh, A. Pawlowski, K. Buchholz.
A New Pathway for the Synthesis of Oligosaccharides by the Use of non-Leloir glycosyltransferases.
Biocat. Biotrans. 2006, 24, 157-165.
J. Seibel*, R. Beine, R. Moraru, C. Behringer, K. Buchholz,
Enzymatische Oligosaccharidsynthesen: vom Gen zum Produkt
Nachrichten aus der Chemie 2006, 2, 110-114.
J. Seibel*
2005
Synthesis of δ-lactam (2-oxopiperazine) inhibitors of elastase
Journal Chemical Research 2005, 12, 826-832.
J. Seibel, S.J. Macdonald, C.J. Schofield*.
Biocatalytic and chemical investigations in the synthesis of sucrose analogues
Tetrahedron 2005, 61, 7081-7086.
J. Seibel*, R. Moraru, S. Götze,
Microwave-assisted Glycosylation for the Synthesis of Glycopeptides
Carbohydr Res 2005, 340, 507-511.
J. Seibel*, L. Hillringhaus, R. Moraru.
Investigations of the transfructosylation reaction by fructosyltransferase from B. subtilis NCIMB 11871 for the synthesis of the sucrose analogue galactosyl-fructoside
J. Biotechnol 2005, 116, 347-357.
I.-E. Baciu, H.-J. Jördening, J. Seibel, K. Buchholz*,
2003
Chemoenzymatische Synthese von Oligosacchariden und glykosylierten Naturstoffen
Transkript (Sonderheft Nachhaltige Biokatalyse) 2003, 9, 40-41.
J. Seibel*, K. Buchholz,
Synthesis and evaluation of delta-Lactams (Piperazones) as elastase inhibitors.
Bioorg Med Chem Lett. 2003, 13, 387-389.
J. Seibel, D. Brown, A. Amour, S.J. Macdonald, N.J. Oldham, C. J. Schofield*,
The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity.
Bioorg Med Chem Lett. 2003, 13, 3853-3857.
J.J. Turnbull, M.J. Nagle, J. Seibel, R.W. Welford, G.H. Grant, C.J. Schofield*,
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
J. Biol. Chem. 2003 , 278, 1802-1806.
J.M. Elkins, K.S. Hewitson, L.A. McNeill, J.F. Seibel, I. Schlemminger, C.W. Pugh, P.J. Ratcliffe, C.J. Schofield*.
2002
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
Biochem. J. 2002, 367, 571-575.
L.A. McNeill, K.S. Hewitson, T.D. Claridge, J.F. Seibel, L.E. Horsfall, C.J. Schofield*.
